Hole (opening), Disk or Stud (projection method) - the key is placement of the opening device relative to:
1) the pivot pin
2) modification of the handle to access the device (if any)
3) size of the device
4) size of you hand
5) blade thickness and weight
Although I prefer opening holes (whether Spydie, slotted or otherwise) over other gizmos, there are Spydies where the combination of the afore-mention factors make the particular knife undesireable to me (even a Spydie - heresy!)
Two main reasons for preferring the hole over the projection method is that when your thumb enter the hole, your tissue is forced into the hole and "locks" in. Too many times I find that on a quick-open, my thumb slides off of a stud on the arc around the pivot - dropping my thumb down onto the blade. On a large blade, this generally is not a problem, but on a mid-size to small blade, it is very dangerous. From a industrial design point-of-view, subtracting mass and bulk is often better than adding mass and bulk.
I think one reason that it is so easy to get addicted to continual acquisition of knives is that find a knife where the sweet spot is just right for you is not easy.