Ken,
I admit to knowing next to nothing about custom knives. I didn't know they existed 18 months ago. My learning curve has increased since finding the Forums.
To answer your question, for me it would have to be an Ed Fowler, "Pronghorn" or better yet, a Damascus Bowie. Why? His style is so unique. I had a chance to talk to Ed at my first knife show, for 20 mins. You have to love the guy. His knives are magic in your hand. It may be a crime to own one of Ed's knives and not use it, since that's what they're made for, but I'm not a hunter. A purveyor once told me they're not collectable, just an expensive using knife. Practical or not, that's what I would own.
PhilL