Well I currently own, or have owned in the past, a fair amount of Spydies: Chinook, Lum ti tanto, Delica, large Dyad, small Dyad, Pro Venator, Pro Grip, Ladybug, Dragonfly, Rescue Jr., and probably a few others that don't spring to mind right now. If I had to pick just one? It would be a battle between the small Dyad (w/micarta scales) and the SS Pro Grip (plain edge). Why? The small Dyad is more office friendly and gets more use than all my other Spydercos. The Pro Grip gets used less, but appeals to me on a much more basic level. Can't really explain it. The fact that the Pro Grip is practically bombproof might be a factor, though!
So ... in the office I'd pick the small Dyad. Outside the office, the Pro Grip would get the nod.