Some knives are more lefty than others. IMHO there are three tasks to using a knife: Drawing, Opening, Closing.
For Drawing, make sure the clip is reverseable for a left front pocket carry.
For Opening, make sure the opening help (stud, disc, hole, kick, etc) is available on the other side (reverseable is ok too).
For Closing, look at the lock. I have a few righty liner locks, and while I CAN close them, it's easier to close a proper lefty liner lock. Benchmade AXIS is great, and Lockbacks are poor but ok. Basicly, I like a lock I can use to close the knife one handed without switching my grip on the handle.
I like the Benchmade AXIS locks. Specificly, the Griptilian series would work well, and is one of the best AXIS lock values in the Benchmade line. My favorite Benchmade is the 940.
Hope this helps,
Overlord in Colorado