Lock reliability remains a critical issue, not just for defensive knives, but for utility knives as well. People really working with their knives tend to end up in all kinds of weird situations that can stress the lock.
For me, the advantage of the rolling lock and axis lock are reliability. Most liner locks, in fact most well-done lockbacks, are plenty strong for me. But among the axis lock's various assets, extreme reliability features high for me. And believe me, stabbing type motions aren't the only motion to worry about -- in fact, I'd bet that torquing the knife during utility work is responsible for more stitched fingers than stabbing motions.
Now, if you're not going to use your knife hard, the argument that these newfangled locks are just overkill that appeal to people who irrationally want whatever is new, might apply to you. But if you are going to actually use your knife, you're putting your fingers at risk. Liner locks fail for a number of reasons, not just the right blade-tang interface geometry, but from white knuckling when the liner sticks out too far, from torquing when the washers are too thick or small in diameter, and from changes in geometry when the frame isn't extremely well-made. Locksbacks fail when there's just a little lint in the mechanism (which is open and appears to attract such lint), when the locking tooth wears down a little, or when the palm accidently disengages the very-open release button.
These aren't guesses, these kinds of problems have been documented over and over. Yes, I realize there are people who have used X or Y kind of lock without a problem for years, but this is a game of probability.
Safety is something that should always be taken seriously. As safer mechanisms come out, a smart person would do well to take a look at them. And we all realize that safety will never be 100% assured -- but that's no reason to give up and say, if I'm not 100% safe, I'll just use a fixed blade all the time. Instead, figure out what is and isn't safe about the current technology, and move on when a better technology comes out.
The rolling lock and axis lock appear to be extremely reliable. So does the integral lock, which functions differently enough from the liner lock that I don't lump the two together -- not to mention the fact that the integral lock does not use the liner, it uses the whole frame.
In short, depending on how you use your knife, the reliability of these new locks are very much a feature worth paying $$ for.