I just got the 408RWS-B which is the S30V, Brass, & Rosewood version. It is an amazing knife with a hair shaving sharp edge out the box. I also have the folder in S30V. Ditto on the edge. Both have outstanding blades and very high quality but both are heavier than the 420HC.
I bought my brother the Kalinga folder in 420HC and it was not as sharp...but sharp none the less. If you like/have experiance with Buck's 420HC you'll probably like this one too. But I suggest paying the $110 to get the 408...its a beast and you'll love it. I'm in love with all my Buck knives or at least most of them.
Either version should be great for skinning large game but I've not had the opportunity with the 408...but I will.