Sal, to echo many of the sentiments here, what *I* look for in a lock that keeps the blade closed are;
good resistance to opening, if the blade is pulled open any angle below 30 degrees or so (approx), the lock should simply pull the blade back into the handle scales (all my Spydie lockbacks do this, they pull the blade back in quite aggresively
positive auditory and tactile feedback that the blade *IS* closed securely, i want to see, hear, and feel the blade fold into the handle with an authoritative, tactile *snap*, my Spydie lockbacks and my Victorinox SAK's do this, the Vics *DO* have a superior closing "snap* than my Spydies, there is *no* doubt when i close a SAK that it's closed
resistance to accidental deployment, in order to open my knife, *I* need to take positive action to thumb it open or pull it open via nail-nick, i also perform the carpet drop test, SAK's and lockbacks invariably pass with flying colors, framelocks don't fare so well, ball locks are unpredictable
basically, in "real world" use, i've found my Vics and lockback Spydies utterly reliable and have no problem trusting them completely, my framelock Spydies (Cricket and Karambit) *DO* open with an authoritative click and lock securely with no sign of bladeplay, however, they lack the authoritative, positive *snap* on closing that i find in my lockbacks/slipjoints, they feel slightly "mushy" when closing, and lack any true resistance to opening or bias-towards-closed, i *know* they're safe, and i do trust them (well, i trust the Cricket, the Karambit scares even *ME*

) i just wish they gave a more positive signal that they were closed
when i had a Benchmade Minigrip for a few weeks (i decided i didn't like it and sold it), i never felt confident in the Axis Lock, the use of fragile appearing springs to hold the lockbar in place seemed like a flawed design from the start, techie for the sake of being techie, too mechanically complex for it's own good and far too many potential failure points, i know this isn't the case, and the Axis is one of the best locks out there, but i never truly felt comfortable with it, i get a similar feeling from the Spydie ball-bearing lock, i know it's a reliable, simple lock, but after dissasembling my Delica 4 trainer just for the heck of it, to see how it was put together, and seeing how simple a lockback really *IS* (lockbar, bent spring and spring holder) the BB lock seems, well, overdesigned and "complicated"
the Dodo responds randomly to the carpet drop-test, sometimes opening slightly, sometimes not, i *have* pushed the blade of the Dodo open a couple times when carrying in pocket, thankfully, i was pushing on the swedge and was able to close the blade before it drew blood
so, to make a long post longer, i prefer lockbacks, not the most sophisticated lock by a longshot, but simple, time tested, and reliable, that bias-towards-closed feature is really important for a pocketknife, and slippies and lockbacks do it well
now that i own a D4 Wave, i have all the advantages of a fast-opening "assisted opening" blade, with the time-tested safety of the lockback, and as an added advantage, the Wave gives me the versatility of being able to decide if i want to "assist" the opening of the blade by using the Wave, or simply draw it straight up and not wave it open, but open it manualy, as an added advantage, a safety lock (like on the Kershaw/Onion SpeedSafe knives) is not needed