Quite probably. Certainly, the number of KO folders in the world that we predicted to exist before we found out about KO's departure is in great excess of the number of KO folders that we now predict will exist.
That said, it's going to mostly depend on the model. Limited runs from KO like the Ti Bump and Tyrade are going to benefit in the long run, but there are some KO folders like the basic Leek that are just so omnipresent that the rarity will not be impacted for a very long time. And it's not as if Kershaw will just stop making half their knives. We don't even know if there won't be future KO/Kershaw collaborations...we just know that if they're in the cards, they're going to be far fewer than we see today. We might start saying KOs in other brands now.
In my mind's eye though, KO is Kershaw and vice versa. I hope future Kershaw folders are at least KO-esque. But we can see in its current line up that KO's influence is felt even in its other designers. For instance, the JYD and RAM both have flippers...and the JYD, shape wise, is fairly KOish anyway.