Let me break this down a bit for ya. The Offset is a large, well built knife that is designed for what ever you may need to cut. The 0300 is a large, TANK built knife that is designed for everything the Offset is, but can take a heck of a lot more.
The Offset is my favorite knife mainly because of style and all the tech that goes into making it. If i were in need of a very heavily built knife, i would choose the 0300 first, just because it can do "dirtier" jobs, but the Offset can handle anything that is thrown at it and can make for a stunning EDC.
The locks are even IMO, so i wont really talk about it. Stud lock is an excellent lock and you just cant go wrong with a Ti frame lock.
0300 has a better steel though, so it will last a bit longer, but the Offset is no slouch with its steel. One just stays sharper longer. Touch em up reguarly, then who cares really? lol
Both are excellent knives over all. the Offset deserves the Knife of the Year award it got in 2005