This won't be a popular answer, but when I'm doing home renovation: mostly, it's a folding utility knife. I will often carry a Spyderco Manix in a nice steel (S110V or SPY27) but the ute knife gets most of the work. I've been using Outdoor Edge, Excel, and Milwaukee utes.
Like previous posters said, I also carry screwdrivers, a prybar, Knipex pliers, and other purpose-made tools. If you want to get work done right, the first time, then leave the Leatherman in the drawer. The trick is to buckle on a small, slim, handy tool belt with a variety of most-needed tools. Alternately, I've been wearing a denim vest with pockets I can stuff with most needed tools...and tape...and screws...and...