I just picked up a Juice S2 this week. I haven't had a chance to carry it to work or for daily chores but my first impression is that the blade, screwdriver, scissors, and can/bottle opener is not as well built as the ones on my Victorinox SAKs. In all fairness it is a bit of apples to oranges comparing a multi-plier to a multi-blade but the Juice tools seem a bit awkward in their appearance and deployment. However, the small plier is the big difference maker as I wanted something to help me pull out fish hooks and crimp lead weights. Time will tell how useful the pliers are in daily use.
If you get a Juice I would recomment still carrying a regular knife. The Leatherman blade will suffice but you could do better.