Fellow lefty here. I don't have the model you're referring to but I do have a few frame locks that are "right handed." I can disengage the locks safely enough with minimal effort. As I'm sure you're familiar, whether lefty or righty, you still have to put your finger in the path of the blade when disengaging the lock. For me personally, my only requirement is that the pocket clip can be mounted on the left side. I don't mind whether a lock is lefty or righty as long as I can mount the pocket clip for left handed carry. Although to caveat that, a left handed frame lock is a wonderful thing. The left handed CRK Umnumzaan I own is every bit as amazing as the press about them claims to be. CRK and DPX are the only companies I can think of immediately that does left handed framelocks out the factory. Hope this helps.