For me, a lock isn't about strength, it's about convenience. Most locking knives can be opened and unlocked with one hand, compared to slipjoint which almost always require two hands. A lock also has to be reliable though, that is why I am cautious about axis locks, and the like. They rely on small springs and small moving parts, more likely to break or jam than a simple linerlock.
So for me, my favorite lock is the frame lock, with some type of lockbar stabalizer, to prevent hyper extension. The liner lock is in second because the frame lock is stronger, simpler and lighter. Both are very easily operated with one hand. The only disadvantage is that when closing the blade, your fingers are in the way of the edge, which can lead to accidents if you aren't fast enough or paying attention.