As with any spring-based opening mechanism, I'd be concerned about such a knife opening accidentally in my pocket. The bigger the activating button is the greater the chance it will open acidentally, the smaller it is the harder it will be to activate.
I'm also pretty sure that in several locations that such a mechanism would clasify the knife as a "switchblade". I don't know how strong or profitable the switchblade market is, but I know that many people are legally prohibited from buying them. This might limit the profitability of such a mechanism.
But still, I think it's pretty cool. I like mechanical stuff.