I also wouldn't EDC either knife, both are too large for my needs.
The Manix 2 is heavier and much wider closed so takes up more pocket space (why I passed on it), while the Grip is lighter but still thick-handled and the handles on the Grip... I passed on it as well because I couldn't get over that cheap/hollow feeling. Despite such reservations, I've seen many videos demonstrating the lengths one must go to to break a Grip's handle - not as easy as its light weight makes you feel. It's a very tough knife. Based on construction and materials, the Manix handle is inherently more durable, but I found it less comfortable which also means less "grippy". What I mean is that while both handles provide good tactile adhesion, the Grip handle fits/fills my hand better and so requires less force to maintain a secure grip in use. As handles go, that is user-preference so handle them both again if you want to decide based on that.
Finally the locks: there is no comparison to the Axis-lock, imho, and no matter how much the Manix2 wishes it had one it does not. Also, demonstrative tests have determined the Axis lock superior to the CBBL... Neither is the Triad-lock and both work fine under most conditions, but the evidence is there. Also the Axis lock is more user-friendly.
So again, I've passed on both knives but how I compared them was as follows:
Manix 2 - better handle but less comfortable, heavier and more space-consuming, inferior lock, but inspires confidence in hand.
Griptilian - comfortable handle but feels cheap/hollow/weak, lighter, superior lock-mechanism, doesn't inspire confidence the way the Manix 2 does.
My $0.02