There isn't a significant difference in the action, locking up or play of the blade.
That being said, the frn does have some flex when they are compressed together. That is only due to the Very small liners (around the pivot area).
Due to that, the G10/steel liner version is Significantly heavier and more stout. But if you are using you knife as a knife, then you shouldn't have to worry about the slight flex.
Mind you I Broke a s110v scales on a manix 2 intentionally to scavenge the blade and put it into a g10 body and it took Much more effort than I thought it would.
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If the decision comes down to s110v vs s30v and being indifferent towards the scales, I would take the s110v or go with a sprint manix 2.
(They have a 52100 string manix 2 coming up, and you can find some cruwear, and other higher end steels on the exchange)