I've not had a Manix 2 open in my pocket yet, but I don't carry one very often, either. The lack of tip-down carry on ball bearing, caged ball bearing, Bolt Action and axis locks is the biggest reason I don't carry any of them much. I know the tip down clip would interfere with releasing the lock, but I've been bitten enough times to prefer tip down almost to the exclusion of tip up only.
I don't know why they don't just drill for tip-down carry. I don't think it would interfere that much.
I would surely like to carry a Manix 2 or Manix 2 XL if it had tip-down carry as an option.