I think the Yojimbo is the more versatile knife for SD. The Yo can be used in any grip including edge in grios and excel.
On the other hand the Matriarch comes with a waved model which cannot be underestimated in an SD situation.
However the most versatile Spyderco for self defense is in my opinion the Waved Endura. My personal favourite is the P'kal. However the P'kal is more ona specialized SD knife where as the Waved Endura is a great knife for all types of SD techniques and makes a great utility knife too.