When I cut open boxes, I only cut the tape- never the cardboard. Cardboard dulls a knife very quickly. If it has to be broken down more, I’ll tear it by hand or
use a box cutter.
That said, that does not look like rust or corrosion. It looks like the glue gunk from packaging tape. With luck, that’s all it is.
Clean it asap.
Then get in the habit of wiping the blade on your shirt tail or something every time you close it. At the end of the day, wipe it again, maybe a tiny bit of Nortons on the blade and joints and blow the lint/ dirt out.