Hi there TJ, haven't tried using endmills to profile 5160/O1, but it should work great, I've used them on 3V/ATS-34/440C and it's left an outstanding finish, only thing I'd recommend is not running too fast, and make sure there's a steady flow of coolant to the tool- otherwise you run the risk of work hardening the steel, then it's a real b*tch to fix (unless you're using carbide that is)