On a well designed lock it probably makes little difference. I never clean the tang but I don't over lube either.
I've never seen anyone that has a knife that fails the 'spine whack' test attribute it to too much lube. Usually if a certain model fails and someone reports it here, you will see one of two things...
A) 15% to 30% of the people say they have the same problem, the rest claim they don't.
B) 95% or more of the people say they do not have the same problem.
I think that A is sign of poor design and/or execution, and B is a sign of poor execution only.
Almost any linerlock can be over stressed and fail, but a well designed one would need a lot of force, in an unusual direction, to make it fail.
A short story: About ten years ago...A knife maker friend had a knife returned. His customer had requested a heavy folding skinner and he was not a knife knut. The maker was experimenting with the liner lock, it was a fairly new idea then, so he thought he'd surprise his customer.
Don't get ahead of me here! You already did? Oh well..
The liner had a definate 'Z' shape to it and the customer said, "I don't want any #%$#$##$ knife I can't close!". It never did fail but my friend made him a new slip joint anyway. Later he 'beefed up' the liner (from 3/32" to 1/8") and gave it to my father. I still can't believe he bent the liner, or how he did it.
Beautiful knife, almost 9" OAL, 440C mirror finish clip blade with a good belly, stainless bolsters and liners and ironwood scales. This maker also makes excellent 'shrunk to fit' sheaths, but not for folders, this knife comes with a 'pancake' sheath.
"Short story?" Far too long! I gotta go...
Steve-O