If I remember right, the patent is up on the spyderco hole, it is now just a registered trademark.Which means you can use a hole of a different shape. Thats why you see lots of knockoffs with triangle shaped holes ( ever heard of cuttin horse knives?... cough cough peices of **** cough cough) If you want to make knives with a round hole and sell them, under your own name you can get a license from spyderco. I think they were doing it at $1 dollar per knife for up to 50 knives per year, or if you were to do more than that like benchamde, you would need to get a special license from them and pay a bigger fee.
Like the others here say though, there has to be a pretty big section of blade exposed when the knife is closed for the hole to be usable. Another thought is that on a narrow blade, you will considereably weaken it by drilling a sizable hole in it. The hole on my delica 98 is around 1/2" in diamter. I'd want at least another half inch of material to be left around the hole, which means the knife has to be at least an inch wide from edge to spine.
And there are the added hassles of drilling hardened steel. Like the others said, carbide mills or drill bits is a must. Also requires either a milling machine or very good drill press as any chatter of the bit will shatter a carbide drill bit.
If you want better thumb purchase while opening the knife, I would suggest you try sanding/filing a way some of the G10 slabs next to the thumbstud. Maybe just round off that whole edge where the first contour is for your index finger. You would only have to thin it down enough that the thumbstud protrudes a little father out beyond the slabs than it already does, and then round the edge off real well so you can sort of get your thumb underneath it too. It could al be done by hand with small files and sandpaper, or even just a dowel rod and sandpaper. And you wouldn't have to alter the liners at all.
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It'll feel better when it stops hurting.