Things to keep in mind with a cartridge type respirator:
Different companies' respirators fit differently to different persons' faces. Man that's an ugly sentence, but what I mean is one brand of respirator may fit someone with a round face better than someone with a thinner face (for example). It's best to get fit tested by a trained professional, but lacking that resource, you can check to see how good the fit is by blocking off the cartridges with your palms and inhaling - if you create a vacuum without any air leaking in, you should be okay.
Also, keep a close shave - stubble can cause air leaks, as can beards anywhere near the seal. If you have any type of facial hair, a full face respirator is the way to go.
Also, NO GLASSES! If you need glasses, you need to order a special lense kit that fits inside the mask.