Although it seems easy to be glib about prions (not that chiral.grolim is), your perspective can change once you've been involved with some cases personally. 100% fatal of course, and a grim neurodegenerative way to go....
Buying or borrowing a knife from a deer hunter? Better have a bit of knowledge to make an informed choice about cleaning/risk etc. What if the risk were 1%, but the outcome would be 100% fatal? No harm to sanitize, eh? Maybe you bought a powerball ticket with
astronomically smaller odds of being a life-changer...
This post should crossover with Kwon Kang's post on pineapples and HAP40, as (one) effective sterilization process involves proteolytic enzyme treatment incl. papain, cousin of bromelain, (thiol peptidase in pineapples that will remove your fingerprints r tongue papillae) in an enzyme/detergent process. In fact his post on pineapple/HAP40 had me thinking about bromelain, peptidases, oxidation etc, and prompted my response here when I read the OP.
Prions can and should be a real concern, not only where North American cervids (deer, elk, moose) are hunted and may have CWD, but also because
plants are an important reservoir and vector. (PSA---most folks are unaware of the prion/plant reservoir and vector)
USGS map of CWD distribution
Distribution of chronic wasting disease in North America, May 2015. Credit: U.S. Geological Survey.
http://www.foodsafetynews.com/2015/...very-about-spread-of-chronic-wasting-disease/
The question then became: Can these prions bind to plants?
Surprisingly, we found that they do bind to plants very efficiently, he said. Even more surprisingly, plants infected with the prions were able to transmit the disease when animals were fed the contaminated plants.
And why do you think so many pathologists had infections?
Journal of General Virology (2005), 86, 869878
An enzymedetergent method for effective prion
decontamination of surgical steel
(excerpts):
"Prions, transmissible agents that cause CreutzfeldtJakob disease (CJD) and other prion diseases, are known to resist conventional sterilization procedures. Iatrogenic transmission of classical CJD via neurosurgical instruments is well documented and the involvement of lymphoreticular tissues in variant CJD (vCJD), together with the unknown population prevalence of asymptomatic vCJD infection, has led to concerns about transmission from a wide range of surgical procedures.
"Surgical stainless steel is capable of binding prions avidly
and acting as a remarkably efficient reservoir of infectivity
(Flechsig et al., 2001; Zobeley et al., 1999)."
...."The prion-degrading reagents identified in this study are readily available, inexpensive, non-corrosive to instruments, non-hazardous to staff and compatible with current equipment and procedures used in hospital sterilization units."
(results and discussion are too soporific for here.....heh)
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As for "germs" in general, I'd much rather get tularemia from rabbits or brucellosis from bison or bubonic plague from squirrels or Lyme disease etc etc etc than any prion infection...
You can read a bit about prions and CWD here:
http://www.cdc.gov/prions/cwd/index.html
good luck