My understanding:
If you start with a tough steel, nail your geometry and temper back the thicker section (spine) of the blade, you will have a FAR more resilient knife than you would if you left the spine unhardened. If you leave the spine with a spring temper, and the geometry of the knife is designed to its task, it will be essentially impossible to seriously damage the blade through intended use.
Nearly any blade, no matter how thin or hard, is virtually immune to damage from forces applied in plane (in other words from edge to spine or vice versa). It is side loads that are most likely to cause blade damage. From a strength perspective, you adjust spine thickness and geometry based on what sort of side loads/twisting/etc. that the blade is likely to encounter.
In addition to thickening the spine, you can also use a differential temper. This temper will allow the thicker sections of the spine, which are more prone to cracking under deflection, to withstand a greater degree of deflection prior to cracking. Essentially as thickness increases, minimum bend radius increases for a given heat treat. Increasing the temper temperature of a steel of a given thickness will generally decrease (improve) the minimum bend radius before cracks form.
Take steel that has not been heat treated and compare it to steel that has. All geometry and alloying being the same, steel that has not been hardened will reach its elastic limit prior to hardened and tempered steel. Steel that has been insufficiently tempered will essentially fracture prior to reaching its elastic limit (snap before it takes a permanent bend). There are a few youtube videos that I can't look up right now, but I think are from 'Real Engineering' that visually depict the relationship between hardness, elastic, and plastic deformation in a given steel.
So basically if you temper the spine back on a knife with appropriate geometry (think full flat or convex grinds, but tall saber grinds and the like also work), you allow the knife to undergo a deeper bend before they start cracking. It also may, depending on the as tempered hardness of the knife you are comparing it to, allow you to bend the knife more prior to the knife taking a permanent bend (undergoing plastic deformation).
What it won't do for you is change the amount of deflection or bend that a given bending moment will create. That is, as far as I am aware, only a function of geometry (thickness) and alloy.
Disclaimer: I am not a metallurgist, so maybe someone who is smarter than I on this score can add info or correct (Larin, you around?).