I wont lie to you I much rather get kicked in the groin once a month than part ways with my knives.
In the end stuff is stuff, so I might just keep the most utilitarian thing.
I'd be ok with parting with knives I have that are famous or popular models but nothing special or very dear to me, like production knives like the SOG SEAL2000 and such
I'd have an even harder time getting rid of knives gifted to me
Then it'd be almost suicide to get rid of the real special ones, be it because they're custom made or because they have some special trait ( like my Busse B11)
The "knife" per se that I have designated as my go-to knife in general for any situation is my Fällkniven A1, so if we're speaking of keeping a literal knife then I keep that one I guess, and then get severely drunk.
BUT the Fällkniven is not the thing I always use to cut, which is in fact the S30V folder on my Leatherman Charge TTi, which is objectively my most used cutting / utility thing.
I make it real easy here but I'd much rather have all the furniture and home commodities sold before my dear knives.
EDIT (because this is such a troublesome and convoluted subject): My Leatherman is also signed by Tim Leatherman himself with a "Best Wishes", so I guess that's one more reason to ditch the Fällkniven and keep the multitool.
SECOND EDIT: Not only is it signed, If I travel to an area where I might really need a medium or big knife, I can buy it in a local shop and just use what the natives use. I can't do that with the Leatherman.
So now, 100% I (bitterly) keep my Leatherman Charge TTi (and try to forget about everything)