Nathan's post on drilling is on the money... Machinists drill tons of holes... I only worked in a machine shop for a summer, and fabrication shops here and there, plus dabble in my own shop and I have drilled thousands of holes, I'm sure a working machinist has probably drilled tens or hundreds of thousands of holes. Their experience and training is invaluable here.
Within reason if you have set up your work and clamped everything in place properly, once the press is loaded up some slop won't matter, provided the bit is true and evenly ground. If you have quality bits, and use them properly so they cut (see the spiral chips) then they will last and last. If you use too little pressure, you're trying to wear a hole rather than drill it. The spindle speed doesn't change this, they need to cut. And usually the drilling speed should be lower than most people realize, or expect. There are plenty of tables out there for drill speeds, based on the diamter of the hole to be cut, the material thickness has next to nothing to do with the spindle speed. Although thicker material will benefit from cooling and clearing of the chips as you go. Google is your friend.
Too many of us think cheap bits are a bargain... They are a cutting tool like a knife, the same things hold true, quality steel, quality heat treat, and proper usage determine edge retention.