XxdrpxX, what would you seal it with out of curiosity? I was concerned when I read kookery's post about it peeling in layers after I'd already started checkering but I didn't see anything like that at all.
I don't change my socks very often. I don't shower very often either (it keeps my perma-socks from getting wet that way). I promise you that your knife would peel in layers too, if it ever got close enough to win a fight with my foot!
Super glue would definitely plug up the checking. If you applied it one groove at a time, and then ran a toothpick through the groove, that might keep it from plugging the checkering. It takes a while for it to harden, since the superglue doesn't seem to bond as quickly with the horn as it does with other things, like socks and feet.
On my knife, it's kind of a mess, and there's really no way to control it once the super glue gets out of the bottle. It's very drippy, and will end up in lots of other places besides the grooves. That may not be too hard to fix if you're handy with sand paper, but you might want to test it in a small area first to make sure the glue is softer than the horn. Otherwise, you'll have nothing but glue left over after the sanding removes horn from the glue. I would be most concerned with scratching the brass.
I used the super glue to seal all the gaps on my knife where water could penetrate and start fermenting or rusting things. It worked better than I expected, and I can liberally drench my knife with blood - er, soap and water - and it totally gets rid of all the DNA evidence - oops, I meant to say "bread crumbs"
