Speed would go to a wave design. From your choices, I'd say spydiehole+ziptie or spydiehole with a wave feature ground into it would be fastest. Omitting wave opening, flipper is going to be the quickest.
Ease of opening easily goes to the flipper.
Unopened, every knife is going to feel comfortable.
For pocket clipping, the flipper has a small disadvantage in that it could bump against the corners. But, I have never noticed anything, nor has a flipper ever opened in my pocket.
Style goes to wave-opening and the flipper. Both are quick and look so very professional.
So overall, wave-opening or flipper is the way to go in my eyes. To be honest, though, I'm fine with all designs.