It's usually easier to design the knife first, and then fit the steel to the knife, rather than vise versa. That said, there's no hard rule about a handle to blade ratio, but the very most important thing is that actually fits in the end user's hand and is comfortable to use.
On larger knives, I'll typically make my handles about 4" to 5", depending on how it will be used, the blade length, size, etc...
After that, it's advisable to "balance" the design, but there's plenty of ways to do this without strictly adhering to "proportions".
At any rate, draw something that looks good to you, and post some pics. We'd love to see what you're thinking about.