Originally posted by Flotsam:
there is a difference between standard superglue (ethyl cyanoacrylate) vetbond (butyl cyanoacrylate) and dermabond (octylcyanoacrylate). as you go from the off-the-shelf superglue to the medical grade stuff, you lose the increased temps associated w/ curing, you gain more flexibility, and you have less tissue toxicity. Dermabond has also been shown to have some antibacterial (bacteriostatic, IIRC) action.
That said, dermabond s typically indicated for small, clean-edged wounds in areas of low tension - in other words, in areas where many wounds would heal just fine w/ little more care than keeping the wound clean. Generally speaking, sealing a wound is not a good idea - you are far more likely to seal infection in, than prevent it from getting in. Big gaping wounds should NOT be sealed, w/ glue - if they are to be closed, they should be cleaned thoroughly (using saline or clean water - not peroxide, bleach or iodine), all foreign material or devitalized tissue should be removed, and then closed in layers (if training/materials/etc... justify) or more reasonably, packed w/ a moistened sterile dressing, and covered w/ a dry dressing.
My preference - clean the wound well, pack deep wounds & cover w/ sterile dressing, or use steri-strips to approximate shallow wounds.