Discussing handles and pocket carry is like discussing boot fit. I can describe what works for me and what doesn't but that might not help you in any way.
112 IS THE MOST BEAUTIFUL KNIFE MADE - I've always thought this. The lines are just perfect to look at. I don't carry mine though. The 110 and 500 always carry better and work better for me. More on this follows...
NO FINGER GROVES - I've owned a few finger grooved knives and they feel good for the first minute or so, but I quickly dislike how they restrict different grips. As somebody else suggested, I think their purpose is to sell knives.
RESTRICTIVE GRIP - As beautiful as the 112 is, even without the finger grooves, I find the grip restrictive. The combination of the front bolster and the more aggressive angle to rear bolster combine to make me feel crowded. I'm 6'3" and wear XL gloves to give you an idea of my hand size. I find the shape of the 500 (and 110) infinitely more comfortable. The one thing I like about the 112 over the 500 is the width, which I prefer in hard cutting, but at that point, I'm moving back to the 110 anyway.
TOO FAT/TOO SHORT - I actually find that longer knives carry better in the front pocket than the 112. They tend to stay more upright in most pockets. The 112 and 500 both end up horizontal in the bottom of the pocket and the problem with the 112 is that it is so fat. It lays across my thigh and is pressed by my pants. In contrast, the 500 is so flat that it rides comfortably, even when it is horizontal.
REAR POCKET CARRY FIXES EVERYTHING - I run a 2.5" seam up the right side of my right rear pocket. It holds a large knife like the 110 upright while leaving the top 1/3 of the grip above the new seam. It's super easy to put in and take out. Practically never pocket ejects. Doesn't advertise the knife. Is comfortable while sitting. Frees up my front pocket (for my Micra, among other things). Keeps my belt free of clutter. Most importantly, it makes carrying a 110 a cinch and once carrying a 110 become easy, I see no reason to compromise on my preferred knife size. I do occasionally carry my 500 because I like it so much, but its small size quickly frustrates me so I go back to the 110. I almost never carry my 112s, even in rear pocket due to my problems with the grip.
Bottom line, the 112 makes my eyes happy and my hands sad.