Here is a good example of how to open a knife with a hole in the blade.
http://www.youtube.com/watch?v=3AiNj6BuES4
I can't say I like his closing method though, it's a little too risky for me.
Especially given the one handed closing method that's mentioned in the MANUAL. Spydies have a choil such that if you put your index finger at the top of the grip, the choil will hit your finger and prevent the blade from closing further. I use this to close the knife against my leg.
I EDC an Endura that I bought this summer. I open it the same way as that guy, just slower.
It really doesn't take much downward pressure on the blade. In fact, if you push too hard downward, you'll torque the pivot point and make it harder to open. Push out, not down.
I too am a thumb stud to thumb hole convert. Now I find thumb studs uncomfortable, even on good knives.
My last knife was a CRKT M16-13z, and I mainly used the thumb stud to CLOSE the blade. I replaced it with the Endura because I wasn't satisfied with the edge retention of the cheaper steel in the zytel models, but I loved the knife otherwise. I like the Carson Flipper better than thumb holes, but they aren't very sheeple friendly.
Of course, YMMV. It's not like there's something WRONG with you if you prefer thumb studs. There's a reason they're still on the market after all.