I actually would like to see more thumb discs, I'd agree that aesthetically they are not as nice as thumb studs, but they are more positive for blade opening in my opinion. Many of the thumb studs are smooth these days, and handle slabs are not scalloped enough to allow for a reliable thumb/stud engagement. Discs might be hard on the thumb but that's simply a result of the extra grip, and I don't sit around flipping my knives open hundreds of times a day. If companies would start rounding their edges better it wouldn't be an issue. It's amazing how many high dollar knives come with sharp edges on handles etc. Discs are design dependent though, some designs just won't allow for easy opening when using a disc.
I also like the fact the thumb disc is truly ambidextrous, in many designs it's much harder to get to the thumb stud on the lock bar side of the knife, complicated further if you carry tip down.
All that said I think we are going to see more and more flipper designs, people love to play mall ninja and imitate auto knives, and a flipper is much more tolerant of inconsistencies in lock bar tension, detent pressure etc. because of the extra leverage most designs I've played with have, especially with the trend of using the thumb stud as a blade stop now.
If I had to rank all of them I'd say depending on design it's a tie between Disc/Spydie hole/flipper followed by thumb studs that are not used as a blade stop, followed by thumb studs used as a blade stop. The reduced leverage on a thumb stud used as a blade stop is just a bad idea, it's asking to have a thumb end up on the blade when opening unless the detent pressure is reduced so much the blade retention is compromised or the pivot is tightened to the point of having enough blade friction that it won't get away from your thumb once you break the detent pressure.