I would nominate the Al Mar SERE knives, both folders and fixed. Although I believe the only fixed ones still produced are the Operator line.
His folders came in several sizes, the larger ones directly aimed at the military market. I think they were the first large folders that were marketed to replace a fixed blade as a SERE/combat field knife.
His fixed blade SEREs with the substantial stainless bolsters and micarta scales were a significant departure from your typical fixed blade sheet metal guard leather handle combat knife at the time.
I think many of his other knives, like the small lightweight very slim and pointy Falcon and Eagle Talon knives for example were quite unique when they came out and possibly influenced other makers along similar lines.
I bought a 3" Al Mar SERE folder in the early 1980s, carried and used it a lot. The lock spring died some time ago but I think I still have it - "somewhere".