I like them. On most knives having bolsters is not going to protect your hand more than the same handle without bolsters would, so I just add them if I think it'll look good and I want to make a dressier knife.
It does add to the weight and to the time spent making the knife. It does add complexity but after you've done it several times that's not so bad.
Guards are cool too, but I'll often keep them or bolsters off of a knife that I'm trying to make at a lower price point, and that I feel has a good enough finger notch up front to prevent the hand slipping forward.
Soldering really adds to guards or bolsters being a PITA- I'll solder a guard now and then, but bolsters always get epoxy in my shop, and guards that fit nice and tight really only need epoxy to seal the joint, rather than solder to make it look finished.
Integral bolsters are of course a lot of fun, and in combination with a tapered tang look impressive. People like them on chef knives with a hidden tang, too.
Speaking of chef knives, those really offer a lot of possibilities for bolster types. I've put all kinds of micarta, G10, stainless, even wood bolsters on chef knives and cleavers. It just makes them look nice.
I've used bolsters on frame and liner locks and I kind of prefer the balance and weight of them without bolsters. A TI bolster on one side of a framelock doesn't screw up weight/balance too much though.
As far as durability I prefer stainless, as NS scratches pretty easy. NS is a lot easier to work with though, and has that nice warm color next to a wood handle.