I like a bit of a gaurd, and countours on the handle for a bit better grip .
I have biggish hands , little 4 inch knives often come with little skiny handles that dont give me a good grip , and I am not real comfy using them because of the fear of slipping .. I end up holding the knife way firmer than needed , and get cramped etc as a result .
a generous contoured , and easily gripped handle is good for me ... a guard is that bit better as long as its not a bowie style set up , just enough to let me easily know that this is the end of the handle when my hand is wet tired and slippery ..