Yes...centre mass theory = biggest target, I am not sure where the argument about why we shoot "centre mass" got to be about this being the most effective location to hit, as opposed to the place we CAN hit when the adrenaline dump has kicked in and our fine motor skills have deteriorated and we are trying desperately not to evacuate out bowls there and then
.

If one needs to put a people out for the count ASAP it is
the brain steam that needs to be hit.
Yes
indeed Cape Buffalo are apparently harder to put on the ground than Elephant, and a damn sight more ornery when riled. The down side to a large calibre double rifle is that there are very few folks who shoot them well, many think there are however the done thing for Africa. As some may recall I am off there next year and talking to my mates here still in the PH game, the vast majority of guides breath a sigh of relief when the client arrives with about anything other than a double rifle. Power certainly does not make up for shot placement. One of the more famous European professional elephant cullers relied upon a 6.5x55 as it has great penetration and he was able to put the bullet just where he wanted them. Out of interest, I am taking my 40 year old .375H&H (got it in 83 myself) as I have spent enough time hunting rabbits with it to know that I am able to hit small targets with it over and over.