Mrd74, I don't know for sure about this, but it looks like it could be. Why don't you contact SOG and ask them if it could. It looks to me like it would be as easy as removing the screws and swapping to the other side.
The clip on the Twitch I and Twitch II are not designed to be switched for left hand carry. Although the clip can be easily removed if desired. It is held on with two screws. if you are looking for a small pocket knife with a reversible clip I would suggest either the Blink or Flash I. Both are assisted opening and have reversible clips for left hand carry.
I hope this helps you out and if you have any other questions let me know.
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