A khukri can be a formidable weapon. I mean if a blade can chop wood imagine what this blade can do on human flesh! In my opinion though there are a few other factors that need to be considered if we are to talk about self defense.
First of all, in general soldiers have far less restrictions regarding what they are allowed to carry versus civilians. Having said that, most likely a soldier won't be asked any questions if he chooses to carry, say, a WWII model while on his way to battle. I bet that there are very few places, if any, in the U.S. where the same can happen with a civilian (I am not talking about taking one in the woods). Further to that, all SD experts agree that the best blade is the one you have with you. Bearing in mind these two factors I don't see how can someone carry a khukri on them without drawing unwanted attention or, even worse, having problems with the LEO.
Then again, one might want to consider the case of indoors SD. There, I could see the use of a khukri. In posts #2 and #3 westfork presented this case in a suitable fashion and even went ahead to suggest pertinent khukris for SD. I also agree about his comments on Yangdu. She is a true lady and one of the best professionals I have come across in my life. Don't just take my opinion on this. See what others, much more knowledgeable than me, say about Yangdu and HI khukris.
Assuming your living space is quite constraint, with the furnitures and all, I would suggest a smaller blade, possibly excellent in thrusting manuevorus.
This is an excellent comment! In SD you need to be fast! How fast? Always faster than your oponent(s). You don't want something that will be unwieldy.
basically what im trying to say is if a khuk was prefered or any weapon for that matter... it should be the one you are most comfortable with

i also suggest you start training with that khuk now.
These are words of wisdom! This is the good thing about Bladeforums: one can find so much knowledge for free from people who are just willing to help. That's it, that's all. They want nothing in return and most likely they will remain unknown for ever. Their knowledge and prudent advice though, may save a forumite's life someday. I find it magnificent!
I hope that helps.