I think it depends upon the person doing the damascus and the purpose of the knife. As far as delamination, I've never actually heard of that happening with a modern laminate blade. Of course, with the amount of time spent doing this kind of construction one would imagine makers would have worked a lot of the kinks out by now.
As to damascus, I HAVE heard about blades that rusted apart because different steels used were really incompatible. These were older blades, as I recall, but not ancient "real" damascus. I think that's why its important to buy from someone who knows what they're doing and won't use steels that are too incompatible. Then again, if its a user knife you can use good cutting steels, and for a display piece you can use steels that will look pretty together.
The way Burt Foster explained his laminating process, he uses his regular thickness of steel, but puts the stainless on the sides to reduce the maintenance and increase the chances that the owner won't be afraid to use the knife. His ideas on this make sense to me, anyway.