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The absolute best option as far as I'm concerned is Resiprene C. Previously used on Busse Basics and Swamprats and now only found on the Scrapyard series of knives. I don't know why it's not more popular. Super durable, impervious to almost all chemicals, absorbs shock from chopping, secure grip, the only downside is it's not "fancy".
I'd say a paracord wrap. Not too fancy but theres no bolsters to loosen or break. No handle slabs to warp crack shatter etc. Paracord wrap can always be replaced for minimal cost.
Res C for big knives ,G10 for small ones. I like skelly handles for EDC or concealed knives
because they are nice and slim. Stainless steel is nice as well on the slim spyderco folders.
550 cord has some advantages as well.
For wood hickory is incredibly durable ,up there with G10. It is not as nice looking as some woods but it's strength is 5 times that of it's closest competitor maple.
Thanks Topher, for a concise & very informative post, with extra points for the nested parens--you must be either a math or computer person.