If I'm outdoors or just doing something casual, I usually have a medium or large knife. That's usually good. In theory, some people are squeamish and could be frightened by a larger knife. In reality, that just doesn't come up very often for me.
I usually carry a smaller "gentleman's knife" at church, around the office, or when I'm dressed up for formal events. That's when I occasionally miss having a bigger knife. For instance, if a random chore pops up where I need to cut something tough, having to apply force with a tiny handle isn't much fun. Smallness isn't the only issue. This category can also involve fancier or prettier knives. While a fancy knife with super steel might hold its edge longer against rougher materials, it can still take scratches from dirt or grit. I always have a harder-use, more work-appropriate beater in the car but it isn't always practical to run out and get it. This situation is rare but it does happen.
One possible fix is better ergonomics overall. I know hard edges and corners look cool. I'd much rather have rounded transitions with no corners or glaring hot spots. A stonewashed blade finish can hold up better. I'd also like to see more options under $80 with steels like 14C28N, VG-10, and N690. In that range, you can have nice things and not worry much about using them.