I have owned a few knives that were of skeletal design. I found that they fit the role of a folder substitute as well. Though they tend to be a transitional knife from carrying folders to full on scaled fixed blades.
That being said, I have been toying with the idea of going back to a Becker BK11 with some mods and I will make a clipped leather pocket slip for it. Once the front finger notch is opened up a bit, the knife allows for a four finger grip (XL width gloves). The San Mai BK11 was ran a bit harder and takes a killer edge.
For now I am planning on making a clipped leather or kydex pocket slip for my CPK EDC. The reasoning being that I carry and use it at work. While I do work in a fridge (Butcher), I don't mind the cold. I normally use it for boxes, some plastics, other things (normally not meat now), though I do wash it. While I have been using the knife, I have had some rust and pitting under the slabs, and until I get the time to make a second set of slabs, leather or kydex will be faster.
The lack of scales will allow me to continue to use the knife I love, while easing the maintenance aspect. Since I will no longer have to remove the scales every other day to stop any corrosion from setting up shop (again).
The ease of maintenance and ease of carry are the two main reasons that I can see using a skeletal knife.
As long as the ergonomics of the tang are not abrasive, has broken corners, and your not going to be pushing the knife to the requirement of needing full slabs to prevent hot spots, it may be a quality carry option that would otherwise be looked over. If a CPK EDC is a bit too large with the slabs, I don't see why one shouldn't try a knife without slabs and see how it fits your particular daily use.