What Page said as far as thickness before HT goes.
I will respectfully disagree with Nate on the "2nd to last" part. Sharpening is the VERY last step I take, because a knife becomes extremely dangerous to work on once it is sharp. Do everything, and I mean EVERYTHING you intend to do to finish a knife out before you sharpen. This includes taking pictures and making sheaths. In the construction of knives we hold on to them in every possible way, except how you're supposed to. If there is a chance for a blade to bite you, eventually it will, and if you're even halfway decent at putting an edge on a blade, those cuts can very easily be to the bone, sever tendons and ligaments, etc. Better to play it safe IMHO.
-d