Sort of. I have the Single Six and the MKII. Of the two, for survival purposes, the semi-auto is definately a little more gun. Reloads faster, has a touch more velocity, and is probably not quite as loud, since it lacks a cylinder gap which would have allowed loud exhaust gasses to exit.
Adjustable sights on both are quite good. Reliability is quite good, assuming you have a cleaning rod, chamber brush and oiler with you.
For most hunting situations, the slow reloading of the SS will not be a liability. However, if your survival situation takes a bad turn and you end up in a protracted shootout (meaning needing more than 1 cylinder of bullets to solve your problem), the slow rate of reloading could easily get you killed.
If you can shoot an example of each one, pick the one you shoot better.