Generally when you hear of a Frame lock or Liner lock failing, it is because the lock bar develops the habit of slipping off the lock face, or if it is used hard, the lock bar deforms or breaks.
As it was originally designed by Michael Walker, the liner lock should stick and develop play like the other locks, but knives are almost never made that way now-days.
Joshua,
I think you are confusing lock longevity with lock reliability.
I was asking what you meant by a frame lock "going". If by "going" you mean the lock will start to fail due to slippage of the lock face, then are you saying that a knife will over its life eventually start to slip off the tang?
From my experience, as the liner or frame lock moves accross the tang due to wear it becomes more reliable, not less. Some poorly made liner locks slip because they do not engage far enough and by giving them a few good flicks the lock up usually improves by the liner moving over.