Well Spyderco offers complementary sharpening for the price of $5 which covers shipping and handling and they do a really good job. But really sharpening with a Spyderco Sharpmaker is very easy, pretty much fool proof, if you start with a well profiled knife and don't let it get too dull. The Spyderco knives obviously have a suitable geometry. So if you go with a Spyderco knife+Sharpmaker, it really doesn't matter how many animals you skin (the Sharpmaker can also be carried and used in the field), you should be set for life. You can chose between a steel that has higher abrasion resistance which equates to longer edgeholding *on abrasive materials* but takes longer to sharpen, or something a little quicker to sharpen with a little lower abrasion resistance. VG-10 and S30V come to mind. If you want a fixed blade, look at BRKT, they use A2 which has limited abrasion resistance but is quite tough and very easy to sharpen.
If you want to go custom I would follow Cliffs advises and look for a maker that uses carbide rich steels at high hardness such as Phil Wilsons 10V.
If you want to go custom I would follow Cliffs advises and look for a maker that uses carbide rich steels at high hardness such as Phil Wilsons 10V.