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I used to prefer thumbstuds, but after using a Spyderco, I'm completely sold on thumbholes. I even got my Mini Grip with a hole instead of a stud.
I was "Spydie dropping" a Buck 110 five years before there was a Spyderco knife.
Knives have holes where the pivot is (obviously)... you should be just as "worried" about that hole as any other hole.
Striders have opening holes (albeit not round) and they're still considered prybars.
Knives aren't for prying. Mini Ti pry bars aren't that heavy nor big, get one.
+1
You can't spydie drop a knife with thumbstuds.
A little off topic, but what's a spydie drop?