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Or make them really angry. One or the other.
9mm is as low as i'll go with a handgun for self defense. I wouldn't carry that gun loaded with 410, .45 LC is the worst i'd go. Then again, I carry a 1911 with 30 rounds backing it up.
http://www.theboxotruth.com/docs/bot41.htm
I think it would do just fine with the right load. Looks like Federal made a special load just for the Judge.
http://www.gunsholstersandgear.com/2009/01/15/federal-premium-410-handgun-ammunition/
I'd like to see actual balastics testing on that, because honestly... I don't consider .410 to be a man stopper even out of a shotgun, nevermind a rifled handgun. I greatly favor a 230 grain JHP projectile flying at 985 FPS, but you could have guessed that.
That would be good to see. I personally chose the 230 g .45 as well Sig P220.
I think that if a BG was hit with 5 rounds of those .410 loads he would be headed for boot hill.